Takahiro NAKAMA

Project Assistant Professor

Department of Chemistry,
The University of Tokyo,

Takahiro NAKAMA


2015. 3B.S. The University of Tokyo
2017. 3M.S. The University of Tokyo
2018. 9-11Visiting Student, M. Famulok lab., University of Bonn, Bonn, Germany
2020. 3Ph.D. of Science, The University of Tokyo
2020. 4Project Assistant Professor, The University of Tokyo


  • "Metal-dependent activity control of a compact-sized 8–17 DNAzyme based on metal-mediated unnatural base pairing"

    Y. Takezawa, L. Hu, T. Nakama, M. Shionoya

    Chem. Commun. 2024, 60, 288–291.

    [10.1039/D3CC05520E ]

  • "Metal-mediated DNA strand displacement and molecular device operations based on base-pair switching of 5-hydroxyuracil nucleobases"

    Y. Takezawa, K. Mori, W.-E. Huang, K. Nishiyama, T. Xing, T. Nakama, M. Shionoya

    Nat. Commun. 2023, 14, 4759.


  • "Hysteresis behavior in the unfolding/refolding processes of a protein trapped in metallo-cages"

    T. Nakama, A. Rossen, R. Ebihara, M. Yagi-Utsumi, D. Fujita, K. kato, S. Sato, M. Fujita

    Chem. Sci. 2023, 14, 2910–2914.


  • "Protein stabilization and refolding in a gigantic self-assembled cage"

    D. Fujita, R. Suzuki, Y. Fujii, M. Yamada, T. Nakama, A. Matsugami, F. Hayashi, J.-K. Weng, M. Yagi-Utsumi, M. Fujita

    Chem 2021, 7, 2672-2683.


  • "Site-specific polymerase incorporation of consecutive ligand-containing nucleotides for multiple metal-mediated base pairing"

    T. Nakama, Y. Takezawa, M. Shionoya

    Chem. Commun. 2021, 57, 1392-1395.


  • "Sharp Switching of DNAzyme Activity through the Formation of a Cu(II)‐Mediated Carboxyimidazole Base Pair"

    Y. Takezawa, L. Hu, T. Nakama, M. Shionoya

    Angew. Chem. Int. Ed. 2020, 59, 21488-21492.


  • "Allosteric Regulation of DNAzyme Activities through Intrastrand Transformation Induced by Cu(II)-Mediated Artificial Base Pairing"

    T. Nakama, Y. Takezawa, D. Sasaki, M. Shionoya

    J. Am. Chem. Soc. 2020, 142, 10153-10162.


  • "Enzymatic Synthesis of Cu(II)-responsive Deoxyribozymes through Polymerase Incorporation of Artificial Ligand-type Nucleotides"

    Y. Takezawa, T. Nakama, M. Shionoya

    J. Am. Chem. Soc. 2019, 141, 19342-19350.


  • "Metal-responsive structural transformation between artificial DNA duplexes and three-way junctions"

    Y. Takezawa, S. Yoneda, J.-L. H. A. Duprey, T. Nakama, M. Shionoya

    Chem. Sci. 2016, 7, 3006-3010.


Review Articles, Books, etc.

  • Bismuth─Catalyzed Redox Reactions

    T. Nakama

    J. Synth. Org. Chem. 2021, 79, 788–789.


  • "3.4 核酸無機材料"
    "Handbook of Nucleic Acids Science"

    Y. Takezawa, T. Nakama, M. Shionoya

    Kodansha Scientific 2020, p.98–106