Physical Isolation of Single Protein Molecules within Well-Defined Coordination Cages to Enhance Their Stability

R. Ebihara, T. Nakama, K. Morishima, M. Yagi-Utsumi, M. Sugiyama, D. Fujita, S. Sato, and M. Fujita

Angew. Chem. Int. Ed. 2024, , in press

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Stepwise Chemical Reduction of [4]Cyclo[4]helicenylene: Stereo Transformation and Site-Selective Metal Complexation

Z. Zhou, Y. Yang, J. Liang, S. Sato, Z. Zhang, and Z. Wei

Precis. Chem. 2024, , in press

[10.1021/prechem.4c00064]

Molecular Cylinders with Donor-Acceptor Structure and Swinging Motion

K. Li, S. Yoshida, R. Yakushiji, X. Liu, C. Ge, Z. Xu, Y. Ni, X. Ma, J. Wu, S. Sato, and Z. Sun

Chem. Sci. 2024, , in press

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Crystallization-Induced Dimerization and Solution-Phase Bond Dissociation of Stable Dibenzoolympicenyl Radicals

X. Zhang, H. He, C. Ge, Q. Xiang, S. Sato, M. Lv, X. Chen, and Z. Sun

Angew. Chem. Int. Ed. 2024, 63, e202418261

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Dynamics of Side Chains in Poly(quinoxaline-2,3-diyl)s Studied via Quasielastic Neutron Scattering

R. Inoue, Y. Nagata, T. Tominaga, S. Sato, Y. Kawakita, T. Yamawaki, K. Morishima, M. Suginome, and M. Sugiyama

J. Chem. Phys. 2024, 161, 054905

[10.1063/5.0215603]

Organic Solvent-Induced Structural Changes in a Protein Confined in a Giant Coordination Cage

H. Tamura, T. Nakama, A. Rossen, H. Ishikita, and M. Fujita

Chem. Lett. 2024, 53, upae101

[10.1093/chemle/upae101]

Conformational Analysis of (+)-Germacrene D-4-ol Using the Crystalline Sponge Method to Elucidate the Origin of its Instability

Y. Jung, T. Mitsuhashi, K. Kageyama, T. Kikuchi, S. Sato, and M. Fujita

Chem. Eur. J. 2024, 30, e202400512

[10.1002/chem.202400512]

Cyclic Sesquiterpene–Flavanone [4+2] Hybrids, Syzygioblanes A–C, Found in an Indonesian Traditional Medicine, “Jampu Salo” (Syzygium oblanceolatum)

N. Koga, Y. Saito, K. Miyake, S. Amuti, S. Fukuyoshi, S. Yoshida, S. Sato, Y. Yamada, A. Ikeda, N. Adachi, M. Kawasaki, A. Takasu, S. Aramaki, T. Senda, A. Rahim, A. Najib, G. Alam, N. Tanaka, and K. Nakagawa-Goto

Org. Lett. 2024, 26, 4302-4307

[10.1021/acs.orglett.4c01248]

Chiral Inversion of Thalidomide During Crystal Growth by Sublimation

M. Kira, Y. Shiga, K. Nakagawa, A. Matsumoto, K. Tokita, Y. Terasawa, K. Zhang, K. Tsutao, T. Nakanishi, S. Yoshida, S. Sato, N. Shibata, and T. Asahi

Cryst. Growth Des. 2024, 24, 3133-3139

[10.1021/acs.cgd.3c01030]

Rapid Synthesis of Chiral Figure-Eight Macrocycles Using a Preorganized Natural Product-Based Scaffold

T. Honda, D. Ogata, M. Tsurui, S. Yoshida, S. Sato, T. Muraoka, Y. Kitagawa, Y. Hasegawa, J. Yuasa, and H. Oguri

Angew. Chem. Int. Ed. 2024, 63, e202318548

[10.1002/anie.202318548]

Enantioselective Synthesis of 3-(N-Indolyl)Quinolines Containing Axial and Central Chiralities

K. Yamanomoto, K. Yamamoto, S. Yoshida, S. Sato, and T. Akiyama

Chem. Commun. 2024, 60, 582-585

[10.1039/D3CC05142K]

Rapid Analysis of Trace Amounts of Amino Acid Derivatives by a Formyl Group-Installed Crystalline Sponge

B. Zhou, S. Utjapimuk, K. Yan, R. Dubey, T. Kikuchi, T. Mitsuhashi, and M. Fujita

Chem. Asian J. 2023, 19, e202300969

[10.1002/asia.202300969]

Function and Structure of a Terpene Synthase Encoded in a Giant Virus Genome

Y. Jung, T. Mitsuhashi, S. Sato, M. Senda, T. Senda, and M. Fujita

J. Am. Chem. Soc. 2023, 145, 25966-25970

[10.1021/jacs.3c10603]

Highlighted in "Research Highlight": Terpene synthases in giant viruses

Jan-Stefan Völler

Nature Catalysis 2023, 6, 1102

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Highlighted in "In the Pipeline": Giant Viruses Are Weird

D. Lowe

Science 2024, in the Pipeline, Biological News

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Synthesis of (±)-Zeapyranolactone, a Noncanonical Strigolactone Isolated from Maize, and Determination of Its Overall Relative Configuration

C. Ono-Ogasawara, S. Yamamoto, Y. Ogura, H. Okamura, K. Takaba, S. Yoshida, S. Sato, K. Yonekura, and H. Takikawa

Tetrahedron Lett. 2023, 127, 154695

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X-ray and Electron Diffraction Observations of Steric Zipper Interactions in Metal-Induced Peptide Cross-β Nanostructures

E. Tsunekawa, Y. Otsubo, Y. Yamada, A. Ikeda, N. Adachi, M. Kawasaki, A. Takasu, S. Aramaki, T. Senda, S. Sato, S. Yoshida, M. Fujita, and T. Sawada

J. Am. Chem. Soc. 2023, 145, 16160-16165

[10.1021/jacs.3c04710]

Synthetic Modulation of an Unstable Dehydrosecodine-type Intermediate and Its Encapsulation into a Confined Cavity Enable Its X-ray Crystallographic Observation

G. Tay, T. Wayama, H. Takezawa, S. Yoshida, S. Sato, M. Fujita, and H. Oguri

Angew. Chem. Int. Ed. 2023, 62, e202305122

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Hysteresis Behavior in the Unfolding/Refolding Processes of a Protein Trapped in Metallo-Cages

T. Nakama, A. Rossen, R. Ebihara, M. Yagi-Utsumi, D. Fujita, K. kato, S. Sato, M. Fujita

Chem. Sci. 2023, 14, 2910–2914

[10.1039/d2sc05879k]

Synthesis and Structure Elucidation of Triarylmethyl Radicals with Anthryl Substitution

P. Wang, J. Hu, Z. Xu, Z. Pu, S. Sato, X. Zhang, W. Hu, and Z. Sun

Chem. Commun. 2023, 59, 2015-2018

[10.1039/D2CC06083C]

Synthesis of a Negatively Curved Nanocarbon Molecule with an Octagonal Omphalos via Design-of-Experiments Optimizations Supplemented by Machine Learning

K. Ikemoto, M. Akiyoshi, T. Mio, K. Nishioka, S. Sato, and H. Isobe

Angew. Chem. Int. Ed. 2022, 61, e202204035

[10.1002/anie.202204035]

Photo‑Conversion of Self‑Assembled Structures into Continuous Covalent Structures via [2 + 2]‑Cycloaddition Reactions

M. Inada, A. Udagawa, S. Sato, T. Asahi, and K. Saito

Photochem. Photobiol. Sci. 2022, 21, 2169–2177

[10.1007/s43630-022-00286-0]

Pentagon-Containing Doublet Graphene Fragments with Edge-Dependent Spin/Charge Distribution

Z. Gong, Q. Xiang, K. Li, Z. Xu, J. Hu, Y. Ni, S. Sato, and Z. Sun

Chin. J. Chem. 2022, 21, 2525-2530

[10.1002/cjoc.202200344]

Single-Crystal Structure Analysis of Non-Deuterated Triglycine Sulfate by Neutron Diffraction at 20 and 298 K: a New Disorder Model for the 298 K Structure

Y. Terasawa, T. Ohhara, S. Sato, S. Yoshida, and T. Asahi

Acta Cryst. 2022, E78, 306-312

[10.1107/S2056989022000858]

Structure Analysis of Polyhalogenated Persistent Organic Pollutants by the Crystalline Sponge Method

J. Chen, T. Kikuchi, K. Takagi, H. Kiyota, K. Adachi, T. Mitsuhashi, and M. Fujita

Chem. Lett. 2022, 51, 85-87

[10.1246/cl.210613]

Solvent Effects in the Crystalline Sponge Method: Importance of Co-solvents for Ordering Absorbed Guests

N. Wada, K. Kageyama, Y. Jung, T. Mitsuhashi, and M. Fujita

Chem. Lett. 2021, 23, 9288-9291

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Overcrowded Ethylene-Bridged Nanohoop Dimers: Regioselective Synthesis, Multiconfigurational Electronic States, and Global Hückel/Möbius Aromaticity

K. Li, Z. Xu, J. Xu, T. Weng, X. Chen, S. Sato, J. Wu, and Z. Sun

J. Am. Chem. Soc. 2021, 143, 20419-20430

[10.1021/jacs.1c10170]

Giant Optical Anisotropy in High Temperature Superconducting Cuprate Bi₂Sr₂CaCu₂O_8+δ

K. Zhang, M. Matsumoto, K. Nakagawa, A. Matsuda, G. Shino, S. Sato, T. Ikeda, and T. Asahi

J. Phys. Soc. Jpn. 2021, 90, 113702

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Cycloparaphenylene Double Nanohoop: Structure, Lamellar Packing, and Encapsulation of C₆₀ in the Solid State

Y. Yang, S. Huangfu, S. Sato, and M. Jurícek

Org. Lett. 2021, 23, 7943-7948

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Cycloparaphenylene–Phenalenyl Radical and Its Dimeric Double Nanohoop

Y. Yang, O. Blacque, S. Sato, and M. Juricek,

Angew. Chem. Int. Ed. 2021, 60, 13529-13535 (Highlighted in Swiss Science Concentrates, CHIMIA 2021, 75, 435-436. [10.2533/chimia.2021.435])

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Chemical Reduction of a Nanosized [6]Cyclo-2,7-naphthylene Macrocycle

Z. Zhou, Z. Wei, K. Ikemoto, S. Sato, H. Isobe, and M. A. Petrukhina

Angew. Chem. Int. Ed. 2021, 60, 11201-11205

[10.1002/anie.202100942]

Comprehensive Structural Analysis of the Bitter Components in Beer by the HPLC-Assisted Crystalline Sponge Method

Y. Taniguchi, T. Kikuchi, S. Sato, and M. Fujita

Chem. Eur. J. 2021, 28, e202103339

[10.1002/chem.202103339]

Protein Stabilization and Refolding in a Gigantic Self-Assembled Cage

D. Fujita, R. Suzuki, Y. Fujii, M. Yamada, T. Nakama, A. Matsugami, F. Hayashi, J.-K. Weng, M. Yagi-Utsumi, and M. Fujita

Chem 2021, 7, 2672-2683

[10.1016/j.chempr.2021.08.005]

Crystalline Sponge Method: X-ray Structure Analysis of Small Molecules via Post-Orientation within Porous Crystals. Principle and Proof-of-Concept Studies

N. Zigon, V. Duplan, N. Wada, and M. Fujita

Angew. Chem. Int. Ed. 2021, 60, 25204-25222

[10.1002/anie.202106265]

Absolute Configuration Determination from Low ee Compounds by the Crystalline Sponge Method. Unusual Conglomerate Formation in a Pre-Determined Crystalline Lattice

R. Dubey, K. Yan, T. Kikuchi, S. Sairenji, A. Rossen, S. S. Goh, B. L. Feringa, and M. Fujita

Angew. Chem. Int. Ed. 2021, 60, 11809-11813

[10.1002/anie.202102559]

Preferences of Polarity and Chirality in Triglycine Sulfate Crystals by Alanine Ghost

Y. Terasawa, T. Kikuta, M. Ichiki, S. Sato, K. Ishikawa, and T. Asahi

J. Phys. Chem. Solids 2020, 151, 109890

[10.1016/j.jpcs.2020.109890]

A Case Study of Stereoisomerism with [6]Cyclo[4]helicenylenes

T. Matsuno, Y. Yang, Y. Nanjo, H. Isobe, and S. Sato

Chem. Lett. 2020, 50, 110-112 (Editor's Choice, Inside Cover)

[10.1246/cl.200717]

Crystalline Naphthylene Macrocycles Capturing Gaseous Small Molecules in Chiral Nanopores

T. Matsuno, K. Fukunaga, S. Kobayashi, P. Sarkar, S. Sato, T. Ikeda, and H. Isobe

Chem. Asian J. 2020, 15, 3829-3835

[10.1002/asia.202000876]

Synthesis and Stereoisomerism of [n]Cyclo-2,9-phenanthrenylene Congeners Possessing Alternating E/Z- and R/S-Biaryl Linkages

Y. Yang, Y. Nanjo, H. Isobe, and S. Sato

Org. Biomol. Chem. 2020, 18, 4949-4955

[10.1039/d0ob01064b]

Ineffective OH Pinning of the Flipping Dynamics of a Spherical Guest within a Tight-Fitting Tube

T. Matsuno, M. Someya, S. Sato, S. Maeda, and H. Isobe

Angew. Chem. Int. Ed. 2020, 59, 59, 14570-14576

[10.1002/anie.202005538]

Acyclic, Linear Oligo-meta-phenylenes as Multipotent Base Materials for Highly Efficient Single-Layer Organic Light-Emitting Devices

A. Yoshii, Y. Onaka, K. Ikemoto, T. Izumi, S. Sato, H. Kita, H. Taka, and H. Isobe

Chem. Asian J. 2020, 15, 2181-2186

[10.1002/asia.202000521]

A Nitrogen-Doped Nanotube Molecule with Atom Vacancy Defects

K. Ikemoto, S. Yang, H. Naito, M. Kotani, S. Sato, and H. Isobe

Nature Commun. 2020, 11, 1807

[10.1038/s41467-020-15662-6]

Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids

T. Mitsuhashi, L. Barra, Z. Powers, V. Kojasoy, An. Cheng, F. Yang, Y. Taniguchi, T. Kikuchi, M. Fujita, D. J. Tantillo, J. A. Porco Jr., and I. Abe

Angew. Chem. Int. Ed. 2020, 59, 23772-23781

[10.1002/anie.202011171]

X-ray Crystallographic Observation of Chiral Transformations Within a Metal–Peptide Pore

A. Saito, T. Sawada, and M. Fujita

Angew. Chem. Int. Ed. 2020, 59, 20367-20370

[10.1002/anie.202007731]

Exploiting a C–N bond Forming Cytochrome P450 Monooxygenase for C–S Bond Formation

I. Morita, T. Mori, T. Mitsuhashi, S. Hoshino, Y. Taniguchi, T. Kikuchi, K. Nagae, N. Nasu, M. Fujita, T. Ohkawa, and I. Abe

Angew. Chem. Int. Ed. 2020, 59, 3988-3993

[10.1002/anie.201916269]

Self-Assembly of Coordination Polyhedra with Highly Entangled Faces Induced by Metal–Acetylene Interactions

Y. Domoto, M. Abe, T. Kikuchi, and M. Fujita

Angew. Chem. Int. Ed. 2020, 59, 3450-3454

[10.1002/anie.201913142]

Colletofurans A–E, 1-Octyl-1,3-dihydroisobenzofuran Derivatives from Colletotrichum boninense AM-12-2

N. R. Ariefta, M. Azim, T. Aboshi, T. Koseki, Y. Taniguchi, M. Fujita, and Y. Shiono

Org. Lett. 2020, 22, 3161-3165

[10.1021/acs.orglett.0c00925]

Biomimetic Synthesis of Meroterpenoids by Dearomatization-Driven Polycyclization

Z. Powers, A. Scharf, A. Cheng, F. Yang, M. Himmelbauer, T. Mitsuhashi, L. Barra, Y. Taniguchi, T. Kikuchi, M. Fujita, I. Abe, and J. A. Porco Jr.

Angew. Chem. Int. Ed. 2019, 58, 16141-16146

[10.1002/anie.201910710]

Structural Elucidation of Tenebrathin: Cytotoxic C‑5-Substituted γ‑Pyrone with a Nitroaryl Side Chain from Streptoalloteichus tenebrarius

S. Hoshino, T. Mitsuhashi, T. Kikuchi, C. P. Wong, H. Morita, T. Awakawa, M. Fujita, and I. Abe

Org. Lett. 2019, 21, 6519-6522

[10.1021/acs.orglett.9b02443]

Repeated Evolution of Cytochrome P450-Mediated Spiroketal Steroid Biosynthesis in Plants

B. Christ, C. Xu, M. Xu, F.-S. Li, N. Wada, A. J. Mitchell, X.-L. Han, M.-L. Wen, M. Fujita, and J.-K. Weng

Nat. Commun. 2019, 10, 3206

[10.1038/s41467-019-11286-7]

Crystalline Sponge Method Enabled the Investigation of a Prenyltransferase-Terpene Synthase Chimeric Enzyme, Whose Product Exhibits Broadened NMR Signals

T. Mitsuhashi, T. Kikuchi, S. Hoshino, M. Ozeki, T. Awakawa, S.-P. Shi, M. Fujita, and I. Abe

Org. Lett. 2018, 20, 5606-5609

[10.1021/acs.orglett.8b02284]

Desymmetrization of meso-Dibromocycloalkenes through Copper(I)-Catalyzed Asymmetric Allylic Substitution with Organolithium Reagents

S. S. Goh, S. Guduguntla, T. Kikuchi, M. Lutz, E. Otten, M. Fujita, and B. L. Feringa

J. Am. Chem. Soc. 2018, 140, 7052-7055

[10.1021/jacs.8b02992]

Collimonins A–D, Unstable Polyynes with Antifungal or Pigmentation Activities from the Fungus-Feeding Bacterium Collimonas Fungivorans Ter331

K. Kai, M. Sogame, F. Sakurai, N. Nasu, and M. Fujita

Org. Lett. 2018, 20, 3536-3540

[10.1021/acs.orglett.8b01311]

Stereospecific Ring Contraction of Bromocycloheptenes through Dyotropic Rearrangements via Nonclassical Carbocation-Anion Pairs

S. S. Goh, P. A. Champagne, S. Guduguntla, T. Kikuchi, M. Fujita, K. N. Houk, and B. L. Feringa

J. Am. Chem. Soc. 2018, 140, 4986-4990

[10.1021/jacs.8b00821]

Crystalline Sponge-based Structural Analysis of Crude Natural Product

N. Wada, R. Kersten, T. Iwai, S. Lee, F. Sakurai, T. Kikuchi, D. Fujita, M. Fujita, and J.-K. Weng

Angew. Chem. Int. Ed. 2018, 57, 3671-3675

[10.1002/anie.201713219]