• Organic solvent-induced structural changes in a protein confined in a giant coordination cage

    H. Tamura, T. Nakama, A. Rossen, H. Ishikita, M. Fujita

    Chem. Lett. 2024, 53, upae101


  • Conformational Analysis of (+)-Germacrene D-4-ol Using the Crystalline Sponge Method to Elucidate the Origin of its Instability

    Y. Jung, T. Mitsuhashi, K. Kageyama, T. Kikuchi, S. Sato, and M. Fujita

    Chem. Eur. J. 2024, , in press


  • Cyclic Sesquiterpene–Flavanone [4+2] Hybrids, Syzygioblanes A–C, Found in an Indonesian Traditional Medicine, “Jampu Salo” (Syzygium oblanceolatum)

    N. Koga, Y. Saito, K. Miyake, S. Amuti, S. Fukuyoshi, S. Yoshida, S. Sato, Y. Yamada, A. Ikeda, N. Adachi, M. Kawasaki, A. Takasu, S. Aramaki, T. Senda, A. Rahim, A. Najib, G. Alam, N. Tanaka, and K. Nakagawa-Goto

    Org. Lett. 2024, , in press


  • Chiral Inversion of Thalidomide During Crystal Growth by Sublimation

    M. Kira, Y. Shiga, K. Nakagawa, A. Matsumoto, K. Tokita, Y. Terasawa, K. Zhang, K. Tsutao, T. Nakanishi, S. Yoshida, S. Sato, N. Shibata, and T. Asahi

    Cryst. Growth Des. 2024, 24, 3133-3139


  • Rapid Synthesis of Chiral Figure-Eight Macrocycles Using a Preorganized Natural Product-Based Scaffold

    T. Honda, D. Ogata, M. Tsurui, S. Yoshida, S. Sato, T. Muraoka, Y. Kitagawa, Y. Hasegawa, J. Yuasa, and H. Oguri

    Angew. Chem. Int. Ed. 2024, , e202318548


  • Enantioselective Synthesis of 3-(N-Indolyl)Quinolines Containing Axial and Central Chiralities

    K. Yamanomoto, K. Yamamoto, S. Yoshida, S. Sato, and T. Akiyama

    Chem. Commun. 2024, 60, 582-585



  • Rapid Analysis of Trace Amounts of Amino Acid Derivatives by a Formyl Group-Installed Crystalline Sponge

    B. Zhou, S. Utjapimuk, K. Yan, R. Dubey, T. Kikuchi, T. Mitsuhashi, and M. Fujita

    Chem. Asian J. 2023, , in press


  • Function and Structure of a Terpene Synthase Encoded in a Giant Virus Genome

    Y. Jung, T. Mitsuhashi, S. Sato, M. Senda, T. Senda, and M. Fujita

    J. Am. Chem. Soc. 2023, 145, 25966-25970


  • Highlighted in "Research Highlight": Terpene synthases in giant viruses

    Jan-Stefan Völler

    Nature Catalysis 2023, 6, 1102


  • Highlighted in "In the Pipeline": Giant Viruses Are Weird

    D. Lowe

    Science 2024, in the Pipeline, Biological News

    [in the Pipeline]

  • Synthesis of (±)-Zeapyranolactone, a Noncanonical Strigolactone Isolated from Maize, and Determination of Its Overall Relative Configuration

    C. Ono-Ogasawara, S. Yamamoto, Y. Ogura, H. Okamura, K. Takaba, S. Yoshida, S. Sato, K. Yonekura, and H. Takikawa

    Tetrahedron Lett. 2023, 127, 154695


  • X-ray and Electron Diffraction Observations of Steric Zipper Interactions in Metal-Induced Peptide Cross-β Nanostructures

    E. Tsunekawa, Y. Otsubo, Y. Yamada, A. Ikeda, N. Adachi, M. Kawasaki, A. Takasu, S. Aramaki, T. Senda, S. Sato, S. Yoshida, M. Fujita, and T. Sawada

    J. Am. Chem. Soc. 2023, 145, 16160-16165


  • Synthetic Modulation of an Unstable Dehydrosecodine-type Intermediate and Its Encapsulation into a Confined Cavity Enable Its X-ray Crystallographic Observation

    G. Tay, T. Wayama, H. Takezawa, S. Yoshida, S. Sato, M. Fujita, and H. Oguri

    Angew. Chem. Int. Ed. 2023, 62, e202305122


  • Hysteresis Behavior in the Unfolding/Refolding Processes of a Protein Trapped in Metallo-Cages

    T. Nakama, A. Rossen, R. Ebihara, M. Yagi-Utsumi, D. Fujita, K. kato, S. Sato, M. Fujita

    Chem. Sci. 2023, 14, 2910–2914


  • Synthesis and Structure Elucidation of Triarylmethyl Radicals with Anthryl Substitution

    P. Wang, J. Hu, Z. Xu, Z. Pu, S. Sato, X. Zhang, W. Hu, and Z. Sun

    Chem. Commun. 2023, 59, 2015-2018



  • Synthesis of a Negatively Curved Nanocarbon Molecule with an Octagonal Omphalos via Design-of-Experiments Optimizations Supplemented by Machine Learning

    K. Ikemoto, M. Akiyoshi, T. Mio, K. Nishioka, S. Sato, and H. Isobe

    Angew. Chem. Int. Ed. 2022, 61, e202204035


  • Photo‑Conversion of Self‑Assembled Structures into Continuous Covalent Structures via [2 + 2]‑Cycloaddition Reactions

    M. Inada, A. Udagawa, S. Sato, T. Asahi, and K. Saito

    Photochem. Photobiol. Sci. 2022, 21, 2169–2177


  • Pentagon-Containing Doublet Graphene Fragments with Edge-Dependent Spin/Charge Distribution

    Z. Gong, Q. Xiang, K. Li, Z. Xu, J. Hu, Y. Ni, S. Sato, and Z. Sun

    Chin. J. Chem. 2022, 21, 2525-2530


  • Single-Crystal Structure Analysis of Non-Deuterated Triglycine Sulfate by Neutron Diffraction at 20 and 298 K: a New Disorder Model for the 298 K Structure

    Y. Terasawa, T. Ohhara, S. Sato, S. Yoshida, and T. Asahi

    Acta Cryst. 2022, E78, 306-312


  • Structure Analysis of Polyhalogenated Persistent Organic Pollutants by the Crystalline Sponge Method

    J. Chen, T. Kikuchi, K. Takagi, H. Kiyota, K. Adachi, T. Mitsuhashi, and M. Fujita

    Chem. Lett. 2022, 51, 85-87



  • Solvent Effects in the Crystalline Sponge Method: Importance of Co-solvents for Ordering Absorbed Guests

    N. Wada, K. Kageyama, Y. Jung, T. Mitsuhashi, and M. Fujita

    Chem. Lett. 2021, 23, 9288-9291


  • Overcrowded Ethylene-Bridged Nanohoop Dimers: Regioselective Synthesis, Multiconfigurational Electronic States, and Global Hückel/Möbius Aromaticity

    K. Li, Z. Xu, J. Xu, T. Weng, X. Chen, S. Sato, J. Wu, and Z. Sun

    J. Am. Chem. Soc. 2021, 143, 20419-20430


  • Giant Optical Anisotropy in High Temperature Superconducting Cuprate Bi2Sr2CaCu2O8+δ

    K. Zhang, M. Matsumoto, K. Nakagawa, A. Matsuda, G. Shino, S. Sato, T. Ikeda, and T. Asahi

    J. Phys. Soc. Jpn. 2021, 90, 113702


  • Cycloparaphenylene Double Nanohoop: Structure, Lamellar Packing, and Encapsulation of C60 in the Solid State

    Y. Yang, S. Huangfu, S. Sato, and M. Jurícek

    Org. Lett. 2021, 23, 7943-7948


  • Cycloparaphenylene–Phenalenyl Radical and Its Dimeric Double Nanohoop

    Y. Yang, O. Blacque, S. Sato, and M. Juricek,

    Angew. Chem. Int. Ed. 2021, 60, 13529-13535 (Highlighted in Swiss Science Concentrates, CHIMIA 2021, 75, 435-436. [10.2533/chimia.2021.435])


  • Chemical Reduction of a Nanosized [6]Cyclo-2,7-naphthylene Macrocycle

    Z. Zhou, Z. Wei, K. Ikemoto, S. Sato, H. Isobe, and M. A. Petrukhina

    Angew. Chem. Int. Ed. 2021, 60, 11201-11205


  • Comprehensive Structural Analysis of the Bitter Components in Beer by the HPLC-Assisted Crystalline Sponge Method

    Y. Taniguchi, T. Kikuchi, S. Sato, and M. Fujita

    Chem. Eur. J. 2021, 28, e202103339


  • Protein Stabilization and Refolding in a Gigantic Self-Assembled Cage

    D. Fujita, R. Suzuki, Y. Fujii, M. Yamada, T. Nakama, A. Matsugami, F. Hayashi, J.-K. Weng, M. Yagi-Utsumi, and M. Fujita

    Chem 2021, 7, 2672-2683


  • Crystalline Sponge Method: X-ray Structure Analysis of Small Molecules via Post-Orientation within Porous Crystals. Principle and Proof-of-Concept Studies

    N. Zigon, V. Duplan, N. Wada, and M. Fujita

    Angew. Chem. Int. Ed. 2021, 60, 25204-25222


  • Absolute Configuration Determination from Low ee Compounds by the Crystalline Sponge Method. Unusual Conglomerate Formation in a Pre-Determined Crystalline Lattice

    R. Dubey, K. Yan, T. Kikuchi, S. Sairenji, A. Rossen, S. S. Goh, B. L. Feringa, and M. Fujita

    Angew. Chem. Int. Ed. 2021, 60, 11809-11813



  • Preferences of Polarity and Chirality in Triglycine Sulfate Crystals by Alanine Ghost

    Y. Terasawa, T. Kikuta, M. Ichiki, S. Sato, K. Ishikawa, and T. Asahi

    J. Phys. Chem. Solids 2020, 151, 109890


  • A Case Study of Stereoisomerism with [6]Cyclo[4]helicenylenes

    T. Matsuno, Y. Yang, Y. Nanjo, H. Isobe, and S. Sato

    Chem. Lett. 2020, 50, 110-112 (Editor's Choice, Inside Cover)


  • Crystalline Naphthylene Macrocycles Capturing Gaseous Small Molecules in Chiral Nanopores

    T. Matsuno, K. Fukunaga, S. Kobayashi, P. Sarkar, S. Sato, T. Ikeda, and H. Isobe

    Chem. Asian J. 2020, 15, 3829-3835


  • Synthesis and Stereoisomerism of [n]Cyclo-2,9-phenanthrenylene Congeners Possessing Alternating E/Z- and R/S-Biaryl Linkages

    Y. Yang, Y. Nanjo, H. Isobe, and S. Sato

    Org. Biomol. Chem. 2020, 18, 4949-4955


  • Ineffective OH Pinning of the Flipping Dynamics of a Spherical Guest within a Tight-Fitting Tube

    T. Matsuno, M. Someya, S. Sato, S. Maeda, and H. Isobe

    Angew. Chem. Int. Ed. 2020, 59, 59, 14570-14576


  • Acyclic, Linear Oligo-meta-phenylenes as Multipotent Base Materials for Highly Efficient Single-Layer Organic Light-Emitting Devices

    A. Yoshii, Y. Onaka, K. Ikemoto, T. Izumi, S. Sato, H. Kita, H. Taka, and H. Isobe

    Chem. Asian J. 2020, 15, 2181-2186


  • A Nitrogen-Doped Nanotube Molecule with Atom Vacancy Defects

    K. Ikemoto, S. Yang, H. Naito, M. Kotani, S. Sato, and H. Isobe

    Nature Commun. 2020, 11, 1807


  • Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids

    T. Mitsuhashi, L. Barra, Z. Powers, V. Kojasoy, An. Cheng, F. Yang, Y. Taniguchi, T. Kikuchi, M. Fujita, D. J. Tantillo, J. A. Porco Jr., and I. Abe

    Angew. Chem. Int. Ed. 2020, 59, 23772-23781


  • X-ray Crystallographic Observation of Chiral Transformations Within a Metal–Peptide Pore

    A. Saito, T. Sawada, and M. Fujita

    Angew. Chem. Int. Ed. 2020, 59, 20367-20370


  • Exploiting a C–N bond Forming Cytochrome P450 Monooxygenase for C–S Bond Formation

    I. Morita, T. Mori, T. Mitsuhashi, S. Hoshino, Y. Taniguchi, T. Kikuchi, K. Nagae, N. Nasu, M. Fujita, T. Ohkawa, and I. Abe

    Angew. Chem. Int. Ed. 2020, 59, 3988-3993


  • Self-Assembly of Coordination Polyhedra with Highly Entangled Faces Induced by Metal–Acetylene Interactions

    Y. Domoto, M. Abe, T. Kikuchi, and M. Fujita

    Angew. Chem. Int. Ed. 2020, 59, 3450-3454


  • Colletofurans A–E, 1-Octyl-1,3-dihydroisobenzofuran Derivatives from Colletotrichum boninense AM-12-2

    N. R. Ariefta, M. Azim, T. Aboshi, T. Koseki, Y. Taniguchi, M. Fujita, and Y. Shiono

    Org. Lett. 2020, 22, 3161-3165



  • Biomimetic Synthesis of Meroterpenoids by Dearomatization-Driven Polycyclization

    Z. Powers, A. Scharf, A. Cheng, F. Yang, M. Himmelbauer, T. Mitsuhashi, L. Barra, Y. Taniguchi, T. Kikuchi, M. Fujita, I. Abe, and J. A. Porco Jr.

    Angew. Chem. Int. Ed. 2019, 58, 16141-16146


  • Structural Elucidation of Tenebrathin: Cytotoxic C‑5-Substituted γ‑Pyrone with a Nitroaryl Side Chain from Streptoalloteichus tenebrarius

    S. Hoshino, T. Mitsuhashi, T. Kikuchi, C. P. Wong, H. Morita, T. Awakawa, M. Fujita, and I. Abe

    Org. Lett. 2019, 21, 6519-6522


  • Repeated Evolution of Cytochrome P450-Mediated Spiroketal Steroid Biosynthesis in Plants

    B. Christ, C. Xu, M. Xu, F.-S. Li, N. Wada, A. J. Mitchell, X.-L. Han, M.-L. Wen, M. Fujita, and J.-K. Weng

    Nat. Commun. 2019, 10, 3206



  • Crystalline Sponge Method Enabled the Investigation of a Prenyltransferase-Terpene Synthase Chimeric Enzyme, Whose Product Exhibits Broadened NMR Signals

    T. Mitsuhashi, T. Kikuchi, S. Hoshino, M. Ozeki, T. Awakawa, S.-P. Shi, M. Fujita, and I. Abe

    Org. Lett. 2018, 20, 5606-5609


  • Desymmetrization of meso-Dibromocycloalkenes through Copper(I)-Catalyzed Asymmetric Allylic Substitution with Organolithium Reagents

    S. S. Goh, S. Guduguntla, T. Kikuchi, M. Lutz, E. Otten, M. Fujita, and B. L. Feringa

    J. Am. Chem. Soc. 2018, 140, 7052-7055


  • Collimonins A–D, Unstable Polyynes with Antifungal or Pigmentation Activities from the Fungus-Feeding Bacterium Collimonas Fungivorans Ter331

    K. Kai, M. Sogame, F. Sakurai, N. Nasu, and M. Fujita

    Org. Lett. 2018, 20, 3536-3540


  • Stereospecific Ring Contraction of Bromocycloheptenes through Dyotropic Rearrangements via Nonclassical Carbocation-Anion Pairs

    S. S. Goh, P. A. Champagne, S. Guduguntla, T. Kikuchi, M. Fujita, K. N. Houk, and B. L. Feringa

    J. Am. Chem. Soc. 2018, 140, 4986-4990


  • Crystalline Sponge-based Structural Analysis of Crude Natural Product

    N. Wada, R. Kersten, T. Iwai, S. Lee, F. Sakurai, T. Kikuchi, D. Fujita, M. Fujita, and J.-K. Weng

    Angew. Chem. Int. Ed. 2018, 57, 3671-3675